Sujata V. Bhat

Indian, Natural Products, Organic Chemist, Academic, Industrial, Researcher and Writer

Sujata Vasudev Bhat Ph. D. (born 16 June 1940) is an Indian organic chemist, academic, researcher and writer, known for her contributions in the discovery & development of Forskolin, a plant-derived diterpene used as a therapeutic and nutritional agent. Her other contributions include analogs analogues of Andrographolide, Rohitukine, Integric acid, Neem tetranor-triterpenoids, Helvetolides, Sesquiterpene lactones, flavonoids and pyranocoumarins with anti-HIV, antitumor, antimalarial, insect control and perfumery activities. She has achieved several elegant total syntheses of bioactive molecules. She has also worked on new methods in green chemistry, bio-transformations and drug delivery systems. She has conducted advanced research in biomedical science and natural products chemistry, holds 26 patents for her findings and authors 7 books and 260 research publications.

Biography

Sujata Vasudev Bhat, born in Ankola, on 16-06-1940 in the south Indian state of Karnataka to Nagesh Shanbhag and Ramabai, did her college studies at Karnataka University from where she graduated in chemistry in 1961 and followed it up with a master's degree in 1963 with distinction and 1st rank. Subsequently, she enrolled for doctoral studies under the guidance of S. C. Bhattacharyya, National Chemical Laboratory Pune and secured the degree of Doctor of Philosophy in 1967 from the Savitribai Phule Pune University, Pune and moved for her post-doctoral studies at the laboratory of professor Werner Herz and completed her post-doctoral studies at Florida State University, USA. On her return to India in1972 she joined the Basic Research Centre, of Hoechst Pharmaceuticals, Mulund as Senior Scientist and Head of Natural Products Division and contributed by finding many bioactive molecules from Indian Medicinal plants. In 1984 she moved to Indian Institute of Technology, Bombay as a member of faculty at the departments of Chemistry & Biomedical Engineering, where she set up her research group and served as the professor with Organic Chemistry & Biomaterial specialization till superannuating in 2002 from academic duties as the professor of the department. Subsequently she has set up Advanced Research Laboratory (ARL) in Vaze College with assistance from her student Kedar Vaze and Kelkar education trust.[2] She serves as a Researcher and Advisor to Industries.

Bhat was married to Vasudev and the couple has one son Ashish and daughter in law Supriya.

Legacy

Sujata V. Bhat is A woman achiever, who is a skilled and committed researcher and excellent teacher, known to have been involved in researches on terpenoids and alkaloids and have contributed to the structural elucidation of a number of them. It was during these investigations, she discovered new skeletal types in Sesqui- and diterpenoids. Based on her researches, she proposed correctly the structure and absolute Stereochemistry of Forskolin, the molecule currently well-known for Adenylate cyclase enzyme stimulation and various biological activities. In addition, she has made significant contributions in the fields of synthesis of bioactive natural products, and the identification of numerous new bioactive compounds from nature. Her other prominent contributions include analogues of Andrographolide, Rohitukine, Integric acid, Neem tetranor-triterpenoids,

Helvetolides, Sesquiterpene lactones, flavonoids and pyranocoumarins with anti-HIV, antitumor, antimalarial, insect control and perfumery activities. Dr. Bhat has achieved elegant total synthesis of bioactive natural molecules with interesting bioactivities. Her synthetic strategies include

  • Utility of Formyl-cyclohexadienone for various condensation reactions to yield a variety of Skeletons such as -forskolin- analogs, taxadiol, Cinnamolide, Polygodial, Drimenin etc
  • Synthesis of Isozonarol, Avarol, hetero-decalins, Qussinoid skeleton, etc.
  • Green chemistry cyclic ethers using catalysts such as Zeolite, clay, ion-exchange resins.
  • Utility of Sulfolene –Regioselective alkylation followed by de-sulfonation, which yielded retinol related polyenes. By altering reaction conditions isomeric polyenes were obtained.
  • New Retino-benzoic derivatives were synthesized for anti-tumour activity evaluation.
  • Amine- peroxides for antimalarial activity evaluations.
  • Chiral sulfoxides condensations subsequent manipulations yielded chiral molecules such β-aminoacids, β-phenylethanol-amines, podophyllotoxin.
  • Biomimetic cyclization in the presence of Chiral LBA gave various tricyclic and teracyclic chiral molecules.
  • Bioconversion and enzyme catalysed reactions yielded chiral molecules.
  • Supported chiral acids were evaluated for asymmetric Prins cyclisation.
  • Perfumery and Cosmetic molecules- Many molecules were prepared.
  • Rate enhancements of various reactions were studied using solid catalysts such as Zeolites, Molecular sieves, Ion exchange resins or Microwaves.

Awards & Honors

  • BHARAT SHIKSHA GAURAV PURSKAR, and a Certificate of Excellence, KTK outstanding Achievers and Education Foundation March 2024.
  • Long Association Appreciation, American Chemical Society, Feb. 2024.
  • The Best Senior Woman Scientist Award, The Pearl Foundation, Madurai, India in 2017., [6]
  • Fellow of Maharashtra Academy of Sciences in 2001.[7]
  • VASVIK award for Woman Scientist in Industrial Research in 1998.[8]
  • Academic Exchange senior faculty, Indian National Science Academy & Royal Society UK,1994.[9]
  • Council member of Indian Chemical Society (Mumbai Branch) for several years.[10]
  • Served as sectional president (Organic Chemistry) organized by Indian Council of Chemists, 2000.[11]
  • Convener, Chairperson in National and International conferences/Symposia. She visited USA, UK, Germany, Australia, Japan, South Korea, Singapore, Pakistan ect. for scientific interactions.
  • Reviewer for several International Journals. Received Awards/recognition from Elsevier, Taylor & Francis, Bentham science publisher.[12]
  • Subject expert for evaluation of research project proposals. DST- Delhi Women Scientist Scheme. D. S. I. R- Delhi for Recognition of R & D Centers of Industries.
  • First rank with distinction & Gold Medal in M. Sc. of Karnataka University 1963.[13]
  • Research Fellowships, Research Associate, CSIR, Delhi, India.
  • Post doctoral Fellowship, Florida State University, Tallahassee, USA.
  • Felicitated by Rotary club Thane, Thane Municipality etc.[14]
  • Newspaper coverage about her research contributions. [Sujata V. Bhat- Sakal, Mumbai, Monday 2nd June, 2003, p.10; Maharashtra times, Mumbai, 4st Feb. 2013; Maharashtra times, Mumbai, 21st Jan. 2014].
  • She was Invited to deliver Lectures at national and international conferences in India and Abroad.

Books Authored

  • Sujata V. Bhat, 2018, Biomaterials, Narosa Publishers, New Delhi, Kluwer Academic Publishers Boston Dordrecht London, 3 Volumes 3nd edition. ISBN: 978-81-8487-137-1.
  • Sujata V. Bhat, B. A. Nagsampagi and S. Meenakshi, 2009, Natural Products: Chemistry and Applications, Alpha Science International Ltd. Published by Alpha Science International. ISBN 10: 1842654055ISBN 13: 9781842654057.
  • Sujata V. Bhat, 2013, Chemistry of Natural Products (Revised Edition), Narosa Publishers, New Delhi. ISBN 10. 8173198241 ISBN 13: 9788173198243.
  • Sujata Bhat Forskolin and congeners Progress in in Chemistry of Organic Natural Products (1993), 62, 1-74, editors, W. Herz, G.W. Kirby, R. E. More, W. Steglich, Ch. Tamm; Springer-Verlag Wien, New York, 1993.
  • Sujata V. Bhat SOLUTIONS in Biomaterials, Narosa Publishers, New Delhi, 2008

See also

  • Forskolin
  • Diterpenoid
  • Andrographolide
  • Rohitukine
  • Integric acid
  • molecules
  • Helvetolides
  • Sesuiterpene lactones
  • Pyranocoumarins
  • Biotransformation
  • Neem

References

  1. SUJATA V. BHAT; Manisha O. Gupta; Roman Pavela; Chitra R. Kamath Insecticidal activity of isoborneol derivatives against Musca domestica adults and Culex quinquefasciatus larvae, DOI: 10.21203/rs.3.rs-3839460/v1
  2. Sujata V. Bhat; Mayur Uttekar; Manisha O. Gupta, Facile Synthesis of Electron-deficient Epoxides Adjacent to Ester and Cyanide Groups, Letters in Organic Chemistry,2024-01,DOI: 10.2174/1570178620666230705123035.
  3. Sujata V. Bhat; Manisha O. Gupta; Kedar R. Vaze, A mild selective method for the conversion of camphene to isoborneol derivatives, Organic Preparations and Procedures International 2024-01-02, DOI: DOI: 10.1080/00304948.2023.2219198
  4. Sujata V. Bhat; Manisha O. Gupta; Jyoti Yadav, Kedar R. Vaze, Solvent free Acetylation procedureOrganic Preparations and Procedures International 2021 | Journal article, DOI: DOI: 10.1080/00304948.2021.1977575 T
  5. Sujata V. Bhat, Sayali J. Mestry, Manisha O. Gupta 2023, Biotechnological Transformation of Citronellene and Citronellol by Fungus Rhizopus oryzae(ATCC 9363) Leading to Interesting Conversions through oxidations and rearrangements, Fungal Gemomics and Biology, Vol. 13, No. 1, DOI: 10.35248/2332-0915.23.13.207, p1-7
  6. S. V. Bhat, R. S. Pawar, P. Rajakannu. 2020, Facile One-Pot Synthesis and Crystal Structure of 2:1 Adducts of Myrcene (or Ocimene) with Benzoquinones, Letters in Organic Chemistry, 17, 624 – 627, doi/10.2174/1570178617666200227110001
  7. S. Fernandes, S. V. Bhat. 2015, Efficient catalyst for tandem solvent free enantioselective Knoevenagel-formal [3+3] cycloaddition and Knoevenagel-hetero-Diels– Alder reactions, RSC Advances, 5, 67706-67711, doi/ 10.1039/C5RA09865.,
  8. R. Pawar, T. Das, S. Mishra, B. Pancholi, Nutan, S. K. Gupta, S. V. Bhat. 2014, Anti-HIV activity of newly synthesized Labdane analogues with o-quinol moiety by inhibiting HIV-1 integrase, Bioorganic Medicinal Chemistry, 24, 302-307, doi/10.1016/j.bmcl.2013.11.014.
  9. 9.M. M. Uttekar, J. Das, R. S. Pawar, B. Bhandari, V. Menon, Nutan, S. K. Gupta, S. V. Bhat. 2012, Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 fusion protein binding, European J. Medicinal Chemistry 56, 358-374 doi/ 10.1016/j.ejmech.2012.07.030.
  10. S. A. Singh, S. V. Bhat. 2011, Synthesis and antimicrobial potential of 3-hydroxy-2-methylene-3-phenyl-propionic acid derivatives, Acta Pharmaceutica, 61, 447-455, doi/10.2478/v10007-011-0034-2 .
  11. S. Vasudevan, S. V. Bhat. 2011, Biotransformation of isoeugenol catalyzed by growing cells of Pseudomonas putida, Biocatalysis andBiotransformation 29, 147-150. doi./ 10.3109/10242422.2011.589898
  12. R. P. Khandare, K. R. Vaze, S. V. Bhat. 2011, Antitumour activity of new retinobenzoic acid analogues, Chemistry and Biodiversity, 8, 841-849 doi/ 10.1002/cbdv.201000116.
  13. S. Mishra, K. B. Upar, S. V. Bhat. 2009, Facile asymmetric synthesis of spongianone analogue through biomimetic cyclization, Tetrahedron Letters 50. 6402-6403 doi/ 10.1016/j.tetlet.2009.08.066.
  14. H. Gurulingappa, Y. R. Jorapur, S. Madhavi, V. Tare, P. Pawar, V. Tungikar, S. V. Bhat. 2009, Larvicidal activity of epoxidation and reduction products of limonoids from Chemistry and Biodiversity, 6, 897-902, doi/10.1002/cbdv.200800105.
  15. H. Gurulingappa, S. Apoorba and Sujata V. Bhat, 2002, Three new tetranortriterpenoids from neem oil, J. Natural Products, 65, 1177-1179. doi.org/ 10.1021/np0105174.
  16. M. V. Risbud, A. A. Hardikar, S. V. Bhat, and R. R. Bonde. 2000, pH-sensitive freeze-dried chitosan-polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery, J. Controlled Release, 31, 23-30, doi/ 10.1016/s0168-3659(00)00208-x.
  17. P. V. Reddy, T. Manisekaraan, S. V. Bhat. 1998, Novel synthesis of Trioxatetracyclo[5.32.04,9,04,11], Tetrahedron letters, 1629-1632, doi/ 10.1016/S0040-4039(97)10858-9.
  18. S. B. Hadimani, R. P. Tanpure, S. V. Bhat. 1996, Asymmetric synthesis of (- )-Podophyllotoxin, Tetrahedron Letters 37, 4791-1994, doi/ 10.1016/0040-4039(96)00937-9.
  19. N. Balu, J. V. Thomas, S. V. Bhat. 1991, Monoterpenic fragment analogues of Apalsmomycin as potential antimalarials’, J. Medicinal Chemistry 34, 2821-2824. doi/ 10.1021/jm00113a021
  20. R. G. Naik, K. Kattige, S. V. Bhat, B. Alreja, N. J. De Souza, R. H. Rupp. 1988,An antiinflammatory cum immunomodulatory piperidylbenzopyranone from Dysoxylum binectiferum: Isolation structure elucidation and total synthesis, Tetrahedron, 44, 2081-2086, doi/ 10.1016/S0040-4020(01)90352-7.
  21. Sujata V. Bhat., A. N Dohadwalla, B. S. Bajwa, N. K. Dadkar, H. Dornauer and N. J. de Souza, 1983, The antihypertensive and positive inotropic diterpene forskolin: effect of structural modification on the activity, J. Med. Chem., 26, 486,-492. doi/ 10.1021/jm00358a006.
  22. W. Herz, S. V. Bhat. A. L. Hall, 1970, Parthemollin, a new xanthanolide from Parthenice mollis, J. Organic Chemistry 35, 1110-1114, doi/ 10.1021/jo00829a054 .

External links

  • https://scholar.google.com/citations;
  • https://orcid.com: 0000-0001-8537-4623;
  • https://patents.justia.com/inventor/sujata-v-bhat;
  • https://www.linkedin.com/in/sujata-bhat;
  • https://sujatavbhat.com
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160
Articles
6
Books
25
Patents